Leucovorin: Uses, Dosage, And Side Effects
Leucovorin, also known as folinic acid, is a medication used to counteract the toxic effects of certain drugs, particularly methotrexate, and as an adjunct in cancer chemotherapy. This comprehensive guide explores the uses, dosage, and potential side effects of leucovorin. — 49ers Vs. Cardinals: Key Player Stats & Game Highlights
What is Leucovorin?
Leucovorin is a derivative of folic acid that doesn't require enzymatic reduction by dihydrofolate reductase (DHFR) to be active. This makes it valuable in situations where DHFR is inhibited, such as during methotrexate treatment. — Lynx Vs. Mercury: How To Watch Live
Uses of Leucovorin
Leucovorin serves several critical functions:
- Methotrexate Rescue: It is used to protect healthy cells from the toxic effects of methotrexate, a drug used to treat cancer and autoimmune diseases.
- Chemotherapy Enhancement: It can enhance the effectiveness of certain chemotherapy regimens, such as 5-fluorouracil (5-FU), in treating colorectal cancer.
- Folate Deficiency: It can treat folate deficiency caused by certain medications or medical conditions.
Dosage and Administration
The dosage of leucovorin varies depending on the specific situation and the patient's individual needs. It is crucial to follow the prescribing physician's instructions carefully. Factors influencing dosage include:
- The dose of methotrexate administered
- The patient's kidney function
- The specific cancer treatment protocol
Leucovorin can be administered orally or intravenously.
Potential Side Effects
While leucovorin is generally well-tolerated, some potential side effects include:
- Allergic reactions (rash, itching, swelling)
- Gastrointestinal issues (nausea, vomiting, diarrhea)
- Insomnia
Important Note: Always consult with a healthcare professional for personalized medical advice. Do not start, stop, or change your treatment plan without consulting your doctor. — Florence County SC: Recent Arrests & Inmate Records
